At JadeBio, we specialize in mass spectrometry based proteomics services. We have proprietary preparation methods for all biological sample types, including cells, animal and plant tissues, biofluids, and environmental and microbial samples. Our mass spectrometry platforms enable deep coverage of the proteome which makes detections of post-translational modifications, including phosphorylation and acetylation, possible. We offer accurate relative and absolute protein quantitation in both genome-wide and targeted discovery modes and have extensive experience in protein characterization such as complete antibody sequencing and antibody-drug conjugate (ADC) characterization.
Our state of the art SRM technology can be applied for biomarker panels of up to one hundred proteins and targeted quantitation of proteins. Absolute quantitation can be done with isotopically labeled reference peptides
Labeled or unlabeled profiling of fluids and solid tissues can be used for biomarker discovery, elucidating mechanism of action (MOA) or a therapeutic, or for understanding a biological system. Isobaric labeling allows for sample multiplexing of up to eight samples, providing for higher throughput and more robust statistics.
We offer identification of unknown proteins from relatively simple mixtures and identification of antibody sequences without prior knowledge of sequence information.
JadeBio can perform single protein analysis for identification of sites modification or additional sequence information. We also offer antibody sequencing for sibling identification or complete sequencing of an antibody. For pull down experiments we can provide immunoprecipitation characterization for identification of co-immunoprecipitating proteins.